Four friends head to Vegas for a 21st birthday in hopes of finding adventure, debauchery and memories that will last them a lifetime. Cameron, the scandalous one of the group decides to record the whole trip, determined to not forget the fiasco . A girlfriend of theirs begs for a ride, convincing them she will disappear as soon as they arrive. When they get to Vegas the guys devise an amazing plan for the night. Things take a turn for the worst when they call strippers that have them travel to a remote location. Little do they know, the strippers work for an organ trafficker. The guys fight for their lives, but eventually get Stripped.

In Manhattan, the vampires Goody and Stacy share an apartment and work and study in the night-shift. Goody was turned in vampire in 1840 by the evil Cisserus, who turned Stacy in the 90s, and they became best friends but Goody never told her real age to her friend. They only drink mice blood and refuse to drink human blood, and they go together to the Vampire Anonymous. Stacy falls in love with her classmate Joey, and soon she learns that he is the son of the vampire slayer Dr. Van Helsing. Meanwhile, Goody meets her former passion, Danny, in the hospital where his wife is terminal. When Stacy gets pregnant, Goody knows that the only way that the child can survive is killing Cisserus, since they would revert to their human ages. But nobody knows where her lair is.

An assassin named Al Simmons is double-crossed and murdered by his evil boss Jason Wynn. Al makes a deal with the devil and returns to earth as Spawn to see his wife. He is ordered by the devil's minion, The Clown, to kill Wynn. Wynn has made a deal with the Clown too and is supposed to destroy the world with a deadly virus that will help start Armageddon and allow Hell to attack Heaven. Spawn must choose between Good and Evil.

It's Alice's birthday and her sorority girlfriends throw her a themed party. Everyone comes as their favorite, sexy character from Wonderland. The Jabberwocky wasn't invited and brings murder and mayhem to the girls' night out.