John 'Hombre' Russell is a white man raised by the Apaches on an Indian reservation and later by a white man in town. As an adult he prefers to live on the reservation. He is informed that he has inherited a lodging-house in the town. He goes to the town and decides to trade the place for a herd. He has to go to another city. The only stagecoach is one being hired for a special trip paid by Faver and his wife Audra. As there are several seats others join the stagecoach making seven very different passengers in all. During the journey they are robbed. With the leadership of John Russell they escape with little water and the money that the bandits want. They are pursued by the bandits. As they try to evade the bandits they reveal their true nature in a life threatening situation.

McCandles Ranch is run over by a gang of cutthroats led by the evil John Fain. They kidnap little Jacob McCandles and hold him for one million dollars ransom. There is only one man brave enough, tough enough, and smart enough to bring him back alive, and that man is Big Jake.

A mutilating knife wielding killer haunts the small Southwest desert town of Mescal. Though most victims have been prostitutes, the first was Travis Mescal, the only son of the town's first family. When the Sheriff proves unable to solve the case, the town leaders invite Investigator Burns to unravel the mystery. Along the way, he confronts tension with the Sheriff, trouble with some citizens, and finally a killer whose motive we've heard before in Ripper-lore.

The last eighteen years in the life of Jesse James, showing his home life in Missouri, his experiences with Quantrill's raiders, his career of banditry with his brother Frank and the Younger brothers, and his attempt to lead a peaceful life after the disastrous attempt to rob the bank at Northfield, Minn.