Two Arkansas firemen, Vince and Don, get hold of a map that leads to a cache of stolen gold in an abandoned factory in East St. Louis. What they don't know is that the factory is in the turf of a local gang, who come by to execute one of their enemies. Vince sees the shooting, the gang spots Vince, and extended mayhem ensues. As Vince and Don try to escape, gang leader King James argues with his subordinate Savon about how to get rid of the trespassers.

Emma and her sister Stacey are normal teenagers in a small town, when a mysterious infection begins to spread. With the town quarantined, and their parents stuck on the other side of the barrier, the girls have a blast eating junk food and sneaking out to go to parties. But when the disease starts to infect people they know, the girls, together with their neighbor Evan (Emma's secret crush), barricade themselves into their home. But it may already be too late, as the infection is already in their midst, and Emma will be faced with a choice: protect her sister or survive the virus.

Sarah tries to start anew in LA, but her neighbours are not what they seem.

Norma and Arthur Lewis, a suburban couple with a young child, receive a simple wooden box as a gift, which bears fatal and irrevocable consequences. A mysterious stranger delivers the message that the box promises to bestow upon its owner $1 million with the press of a button. However, pressing this button will simultaneously cause the death of another human being somewhere in the world, someone they don't know. With just 24 hours to have the box in their possession, Norma and Arthur find themselves in the cross-hairs of a startling moral dilemma and must face the true nature of their humanity.