Duets is a road-trip comedy which revolves around the little known world of karaoke and the whimsical characters who inhabit it. There's the struggling singer who dreams of making it to the big time, a frustrated salesman who ends up on an unexpected road trip, the dysfunctional family performers which includes a con-artist and his long lost daughter, and an escaped convict with the voice of an angel. All roads lead to Omaha, site of a national karaoke competition where this motley group of singers and stars come together for a blow-out sing-off.

A tale told over four seasons, starting in autumn when Juno, a 16-year-old high-school junior in Minnesota, discovers she's pregnant after one event in a chair with her best friend, Bleeker. In the waiting room of an abortion clinic, the quirky and whip-sharp Juno decides to give birth and to place the child with an adoptive couple. She finds one in the PennySaver personals, contacts them, tells her dad and step-mother, and carries on with school. The chosen parents, upscale yuppies (one of whom is cool and laid back, the other meticulous and uptight), meet Juno, sign papers, and the year unfolds. Will Juno's plan work, can she improvise, and what about Bleeker?

A career bank robber busts out of jail (Clooney) with the help of his buddy (Rhames) and kidnaps a US Marshal (Lopez) in the process. When the two cons head for Detroit to pull off their final big scam, the Marshal is put on their case but she finds she is attracted to one of them and has second thoughts about bringing them in.

Leo is 22 and sells his body on the street for a bit of cash. The men come and go, and he stays right here - longing for love. He doesn't know what the future will bring. He hits the road. His heart is pounding.