Madec, an international and unscrupulous entrepreneur, hires the skilled young tracker Ben to guide him through the fearful and barren Mojave Desert during a hunting trip. Unfortunately, however, things will take a turn for the worse, when prideful Madec shoots unintentionally the wrong target, and in a cynical attempt to wash his hands of the irrevocable deed, Madec will try to bribe himself out of this predicament by offering Ben a hefty compensation in exchange for his silence. But as this is against Ben's principles, before long, the unfortunate tracker will run for his life under the fierce and merciless sun. Undoubtedly, the desert is limitless, but on the other hand, so is the desire to survive.

When a film crew moves into an abandoned psychiatric hospital with a shadowy past to shoot a low budget horror film, they get more than they bargained for. The late nights and lack of sleep begin to take a toll, and the longer this crew works, the more the leaky, wet building seems to be coming back to life, feeding off its new inhabitants. As the shoot wears on, members of the crew exhibit increasingly strange behavior leaving those still sane realizing they need to get out of this place before they too succumb to the building's infectious hold, the only problem, the old hospital is not ready to let them go.

Destroyer follows the moral and existential odyssey of LAPD detective Erin Bell who, as a young cop, was placed undercover with a gang in the California desert with tragic results. When the leader of that gang re-emerges many years later, she must work her way back through the remaining members and into her own history with them to finally reckon with the demons that destroyed her past.

The wives of New York gangsters in Hell's Kitchen in the 1970s continue to operate their husbands' rackets after they're locked up in prison.