Three characters make the realization that none of them have ever felt true-fear, so over the course of one night, they set out to trick each other into feeling it.

The gang is pulled out of retirement to investigate a mystery on a familiar zombie-infested island.

Frank Detorre is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ...

It seems everyone is trying to get into heaven; at least those whose time is up. For Lance Barton, a struggling comedian and bicycle messenger, it's the last thing on his mind. His due date upstairs is 50 years away. In the meantime, he's got big dreams to pursue on Earth, such as landing a slot at the final Amateur Night Contest at the famed Apollo Theatre. Lance's has one little problem though - he ain't that funny. Thanks to an over-cautious emissary from heaven, Mr. Keyes, he's going to get hit (literally) with a much bigger problem. Showing that even God has difficulty finding good help these days, the inept minion mistakenly plucks Lance from a traffic accident - before it takes place. Transporting him to the Pearly Gates, or more accurately, the velvet roped-lines of the hottest club around, the error is finally addressed by Mr. King, the streetwise, no-nonsense head angel who manages the place from his plush windowed office. Since returning to his own body on Earth is ...