In the year 2139, the Earth has changed into a virtually uninhabitable place called the Cursed Earth. All of the Earth's population have crowded into the cities across the planet, now known as Mega-Cities. The crimes in these Mega-Cities became so violent and so powerful, that the regular justice system was powerless to contain, then it collapsed completely. However, a new justice system came from the ashes, there were three justice systems in one (police, jury and executioner), they were called Judges. In Mega-City One (formerly, New York City), there was a Judge, named Joseph Dredd, who was the toughest and most stringent Judge in history. One day, he was charged with murder, and was tried and sentenced to life in prison because of it.

The film tells the story of a journalist couple who invite a man and woman into their idyllic village home, but what begins with an informal interview descends into a nightmarish fight for survival.

Chev Chelios survives a fall from the sky, sort of. He's in an unknown location, sedated, while various Chinese are harvesting his organs. His heart is gone, in an ice chest; a temporary in its place. Chev escapes, knowing only the name of the guy with the ice chest. He calls Doc Miles, an unlicensed cardiologist, who tells him there's only an hour's life in the artificial heart: keep it charged. Chev needs to find his own heart and get to Doc for a transplant. He starts his time-limited pursuit of shadowy figures, the ice chest, and his heart aided by Eve, Rei, and Venus - a stripper, a prostitute, and a pal with Tourette's - constantly needing an electric charge to keep going.

Four blue collar astronauts who are stuck together on a Sanitation Station after they bring a mysterious device aboard their ship and all life on Earth disappears. Discovering what happened to civilization is only the first of many galactic-level crises the astronauts will have to face as they are about to come under attack by a mutating rubber duck named Gary, who wants to open a portal to his evil dimension and take over the Universe.