After their wedding, newspaper writers John and Jennifer Grogan move to Florida. In an attempt to stall Jennifer's "biological clock", John gives her a puppy. While the puppy Marley grows into a 100 pound dog, he loses none of his puppy energy or rambunctiousness. Meanwhile, Marley gains no self-discipline. Marley's antics give John rich material for his newspaper column. As the Grogans mature and have children of their own, Marley continues to test everyone's patience by acting like the world's most impulsive dog.

Annie Porter, the woman who was held on a bus with a bomb attached to it that will go off if it slows down. She dated the cop who saved her but broke up with him because he was constantly putting his life in danger. She would then date a guy named Alex who is also a cop but told her that he does a mundane assignment. But she eventually learns that he works for the same unit that the other guy worked for and is also addicted to danger. She wants to break up with but he surprises her with a cruise. She agrees to go. And he's planning to propose to her. But when he notices another passenger act peculiar, he can't help but try to find out what's up with him. He's Geiger, a computer man who designed the ship's systems, who was fired. He then takes over the ship's systems and sets it on a course that will send it into a tanker. Alex tries to stop him.

Fred and Mick, two old friends, are on vacation in an elegant hotel at the foot of the Alps. Fred, a composer and conductor, is now retired. Mick, a film director, is still working. They look with curiosity and tenderness on their children's confused lives, Mick's enthusiastic young writers, and the other hotel guests. While Mick scrambles to finish the screenplay for what he imagines will be his last important film, Fred has no intention of resuming his musical career. But someone wants at all costs to hear him conduct again.

Legendary performer Judy Garland (Renée Zellweger) arrives in London in the winter of 1968 to perform a series of sold-out concerts.