Three women who were good friends in the past get back together for the first time since they were kids to spend time on an island called Black Rock. They meet some local hunters and find out they know one of them from when they were children. After inviting them to join them in a few drinks on the beach, the atmosphere changes into one of panic and horror as the situation and friendships are turned on their head in a brutal confrontation.

Chris Flynn is driving his car for a job interview in another city. However, an accident with a trunk transporting chemical products blocks the highway and Chris looks for an alternative route through the mountains of West Virginia to accomplish his schedule. Due to a lack of attention, he crashes another car parked in the middle of the road with flat tires. Chris meets a group of five friends, who intended to camp in the forest, and they decide to leave the couple Francine and Evan on the place, while Chris, Jessie, Carly and her fiancé Scott tries to find some help. They find a weird cabin in the middle of nowhere, where three violent cannibalistic mountain men with the appearance of monsters live. The two couples try to escape from the mountain men while chased by them.

Christian (Robert Hoffman) and his girlfriend are taking a walk on a deserted beach when they discover a woman's body lying. A closer look proves that she's alive. The next day Christian meets her again at a yacht party and they fall in love. Later at a nearby motel, something weird happens as they prepare to go to bed together: An intruder breaks in and starts beating Christian who accidentally shoots him with his own gun. A few hours later they find out that the corpse is missing and a series of weird incidents takes place.

Alicia arrives in South America to vacation with her cousin, Sara. When Sarah is suddenly called away, Alicia is stuck on a remote island off Chile with three of Sara's friends, including Brink, an American exchange student with a sadistic streak. Bewildered, frightened, and unable to sleep, Alicia's reality becomes a nightmare from which there is no waking. Ancient indigenous rites, disturbing animal behavior, and captivating hypnotic trances come together in an intense exploration into the darkest corners . . . when the games go too far, reality unravels with astonishing and deadly consequences.