An ambitious young executive is sent to retrieve his company's CEO from an idyllic but mysterious "wellness center" at a remote location in the Swiss Alps. He soon suspects that the spa's miraculous treatments are not what they seem. When he begins to unravel its terrifying secrets, his sanity is tested, as he finds himself diagnosed with the same curious illness that keeps all the guests here longing for the cure.

Fed up with her parents' bickering, poor-little-rich-girl Maya (Dylan Penn) moves in with her boyfriend who is squatting in an old, condemned building on Manhattan's Lower East Side. With neighbors that are meth heads, junkies and degenerates, this depraved hell hole is even more toxic than it appears: After a virus born from their combined noxious waste and garbage infects the building's residents, one by one, they succumb to a terrifying pathogen that turns them into bloodthirsty, rampaging killers and transforms their building into a savage slaughterhouse.

For young Charley Brewster, nothing could be better than an old horror movie late at night. Two men move in next door, and for Charley with his horror movie experience, there can be no doubt that their strange behavior is explained by the fact that they are a vampire and his undead day guardian. The only one who can help him hunt them down is a washed-up actor, Peter Vincent, who hosts Charley's favorite TV show, Fright Night. Vincent doesn't really believe that vampires exist, but does it for the money...

With the disappearance of hack horror writer Sutter Cane, all Hell is breaking loose...literally! Author Cane, it seems, has a knack for description that really brings his evil creepy-crawlies to life. Insurance investigator John Trent is sent to investigate Cane's mysterious vanishing act and ends up in the sleepy little East Coast town of Hobb's End. The fact that this town exists as a figment of Cane's twisted imagination is only the beginning of Trent's problems.