Lt. John Dunbar is dubbed a hero after he accidentally leads Union troops to a victory during the Civil War. He requests a position on the western frontier, but finds it deserted. He soon finds out he is not alone, but meets a wolf he dubs "Two-socks" and a curious Indian tribe. Dunbar quickly makes friends with the tribe, and discovers a white woman who was raised by the Indians. He gradually earns the respect of these native people, and sheds his white-man's ways.

Sam Whiskey is an all-round talent, but when the attractive widow Laura offers him a job, he hesitates: he shall salvage gold bars, which Laura's dead husband stole recently, from a sunken ship and secretly bring them back to the mint before they are missed. But how shall he manage to get several hundred pounds of gold into the mint without anyone noticing?

A bandit terrorizes a small Mexican farming village each year. Several of the village elders send three of the farmers into the United States to search for gunmen to defend them. They end up with seven, each of whom comes for a different reason. They must prepare the town to repulse an army of thirty bandits who will arrive wanting food.

Based on Patrick DeWitt's novel, The Sisters Brothers revolves around the colourfully named gold prospector Hermann Kermit Warm, who's being pursued across 1000 miles of 1850s Oregon desert to San Francisco by the notorious assassins Eli and Charlie Sisters. Except Eli is having a personal crisis and beginning to doubt the longevity of his chosen career. And Hermann might have a better offer.