Nurse "Coffy" Coffin leads a double life. During the day, she's a nurse at work. At night, she's an avenging angel on a personal vendetta, tracking down the drug pushers who hooked her younger sister on drugs. Along the way, she meets a honest police detective who also is leading a double life.

Following an ace assassin who is double crossed by gangsters and falls into the hands of rogue surgeon known as The Doctor who turns him into a woman. The hitman now a hitwoman sets out for revenge, aided by a nurse named Johnnie who also has secrets.

In Germany, Hans Beckert is an unknown killer of girls. He whistles Edvard Grieg's 'In The Hall of the Mountain King', from the 'Peer Gynt' Suite I Op. 46 while attracting the little girls for death. The police force pressed by the Minister give its best effort trying unsuccessfully to arrest the serial killer. The organized crime has great losses due to the intense search and siege of the police and decides to chase the murderer, with the support of the beggars association. They catch Hans and briefly judge him.

It is the year 2029. Technology has advanced so far that cyborgs are commonplace. In addition, human brains can connect to the internet directly. Major Motoko Kasunagi is an officer in Section 9, an elite, secretive police division that deals with special operations, including counter terrorism and cyber crime. She is currently on the trail of the Puppet Master, a cyber criminal who hacks into the brains of cyborgs in order to obtain information and to commit other crimes.